CD71 Antibody (DA272)

Description

CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells.1 Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes.1 Therefore, anti-CD71 is a useful marker for highlighting erythroid precursors in normal and neoplastic specimens.2 Increased CD71 expression is also associated with active cell growth and may be seen in various carcinomas.3 — Références — 1. Ponka, P, and C N Lok. "The transferrin receptor: role in health and disease." The international journal of biochemistry & cell biology vol. 31,10 (1999): 1111-37. 2. Marsee, Derek K et al. "CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens." American journal of clinical pathology vol. 134,3 (2010): 429-35. 3. Chan, Kin Tak et al. "Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma." Oncology reports vol. 31,3 (2014): 1296-304.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA272

Isotype

Mouse

Réactivité

Synthetic peptide of human CD71

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)