CD7 Antibody (DA032)

Description

CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin gene superfamily.1,2 It is suggested that CD7 plays a role in T-cell interactions as it is one of the earliest T-cell lineage associated antigens expressed during T-cell ontogeny.2,3 CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoid and myeloid progenitors.1,2,4 CD7 can be used to identify primitive T-cell tumors such as lymphoblastic leukemia if antibodies to other T-cell markers are ineffective. — Références — 1. Stillwell R, et al. T cell signal transduction and the role of CD7 in costimulation. Immunol Res. 2001; 24:31-52. 2. Schanberg LE, et al. Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. Proc Natl Acad Sci USA. 1991; 88:603-7. 3. Chabannon C, et al. Expression of CD7 on normal human myeloid progenitors. J Immunol. 1992; 149:2110-3. 4. Rabinowich H, et al. Expression and function of CD7 molecule on human natural killer cells. J Immunol. 2003; 152: 517-26.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA032

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD7

Localisation

Cell membrane

Usage prévu

IHC (FFPE)