CD68 Antibody (DA030)

Description

Anti-CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; lymphomas are negative or show few granules. This antibody may be useful for the identification of myelomonocytic and histiocytic tumors. Since this detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also stain.1-3 It is often tested together with AACT and Lysozyme to improve its diagnostic accuracy. — Références — 1. Holness CL, et al. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 1993; 81:1607-13. 2. Leong A, et al. Manual of Diagnostic Antibodies for Immunohistochemistry. Greenwich Medical Media Ltd. 2003; p.135-6. 3. Lau SK, et al. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol. 2004; 122:794-801.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA030

Isotype

Mouse

Réactivité

Synthetic peptide of human CD68

Localisation

Cell membrane

Usage prévu

IHC (FFPE)