CD61 Antibody (DA149)

Description

CD61 also known as integrin beta chain beta 3 (ITGB3) is an integrin cell-surface protein associated with cellular adhesion and cell-surface mediated signaling. Immunohistochemical staining for CD61 can be useful in evaluating normal and abnormal megakaryocytes, which can aide in the identification of some hematopoietic malignancies. Anti-CD61 reactivity is also seen in platelets, osteoclasts and macrophages.1-4 — Références — 1. Thiele J, et al. An immunomorphometric study on megakaryocyte precursor cells in bone marrow tissue from patients with chronic myeloid leukemia (CML). Eur J Haematol. 1990; 44:63-70. 2. Thiele J, et al. Megakaryocyte precursors (promegakaryoblasts and megakaryoblasts) in the normal human bone marrow. An immunohistochemical and morphometric study on routinely processed trephine biopsies. Anal Quant Histol. 1990; 12:285-9. 3. Fox SB, et al. Megakaryocytes in myelodysplasia: an immunohistochemical study on bone marrow trephines. Histopathology. 1990; 17:69-74. 4. Thiele J, et al. Megakaryocyte precursors (promegakaryoblasts and megakaryoblasts) in the normal human bone marrow. An immunohistochemical and morphometric study on routinely processed trephine biopsies. Anal Quant Histol. 1990; 12:285-9.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA149

Isotype

Mouse

Réactivité

Synthetic peptide of human CD61

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)