CD56 Antibody (DA028)

Description

CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins.1-3 CD56 is involved in cell–cell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms,4 and is frequently used to identify neoplasms with neuroendocrine differentiation.5,6 — Références — 1. Walmod, Peter S et al. "Zippers make signals: NCAM-mediated molecular interactions and signal transduction." Neurochemical research vol. 29,11 (2004): 2015-35. 2. Skog, Maria S et al. "Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells." Stem cell research & therapy vol. 7,1 113. 15 Aug. 2016. 3. Cohavy, Offer, and Stephan R Targan. "CD56 marks an effector T cell subset in the human intestine." Journal of immunology (Baltimore, Md. : 1950) vol. 178,9 (2007): 5524-32. 4. Swerdlow SH, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. 2008. 5. Kriegsmann, Katharina et al. "Insulinoma-associated Protein 1 (INSM1) in Thoracic Tumors is Less Sensitive but More Specific Compared With Synaptophysin, Chromogranin A, and CD56." Applied immunohistochemistry & molecular morphology : AIMM vol. 28,3 (2020): 237-242. 6. Rooper, Lisa M et al. "INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors." The American journal of surgical pathology vol. 42,5 (2018): 665-671.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA028

Isotype

Mouse

Réactivité

Synthetic peptide of human CD56

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)