CD5 Antibody (DA029)

Description

CD5 is a glycoprotein monomer with an MW of 67 kDa belonging to the scavenger receptor cysteine-rich (SRCR) family of extracellular domain-like structures. It possesses a large cytoplasmic domain suitable for signal transduction.CD5 is a T-cell marker that also reacts with a range of neoplastic B cells, e.g., B-cell Chronic Lymphocytic Leukemia (B-CLL), B-cell Small Lymphocytic Lymphoma (B-SLL), and Mantle Cell Lymphoma. CD5 is expressed in T-lymphocyte subsets and is modulated during cellular activation; however, it does not react with granulocytes or monocytes. 1-4 — Références — 1. Chan JKC, et al. Histopathology. 1994;25:517-536 2. Kasaian MT, et al. Proc of the Soc for Exp Bio and Med. 1991;197:226-241 3. Jones NH, et al. Nature. 1986;323:346-349 4. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement/Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA029

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD5

Localisation

Cell membrane

Usage prévu

IHC (FFPE)