CD41 Antibody (DA275)

Description

ITGA2B encodes CD41, or integrin alpha IIb. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain IIb undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form fibrinogen receptor expressed in platelets that plays a crucial role coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface medicated signaling. CD41 expression has been found on platelets, megakaryocytes, and immature hematopoietic progenitors.1-5 — Références — 1. “Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)” 2. Kato A, et al. J Biol Chem. 2002 Aug; 277(32):28934-41 3. Larkin D, et al. J Biol chem. 2004 June; 279(26):27286-93 4. Karandikar N, et al. Am J Clin Pathol. 2001; 116:204-10 5. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement/Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA275

Isotype

Rabbit

Réactivité

Vimentin

Localisation

Cell membrane

Usage prévu

IHC (FFPE)