CD4 Antibody (DA027)

Description

CD4 is a 55-kD glycoprotein expressed on the surface of T-helper/regulatory T-cells, monocytes, macrophages, and some dendritic cells. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+. Anti-CD4 is used to identify normal T-cells and to aid in the identification of neoplasms of T-cell origin.1-3 — Références — 1. Jasani, Bharat. "Manual of Diagnostic Antibodies for Immunohistology: Leong AS-Y, Cooper K, Joel F, Leong W-M. (£45.00.) Oxford University Press, 1999. ISBN 1 900151 31 6." Molecular Pathology vol. 53,1 (2000): 53. 2. Akiyama, Takashi et al. "CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients." Pathology international vol. 58,10 (2008): 626-34. 3. Garcia-Herrera, Adriana et al. "Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome." Journal of clinical oncology : official journal of the American Society of Clinical Oncology vol. 26,20 (2008): 3364-71.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA027

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD4

Localisation

Cell membrane

Usage prévu

IHC (FFPE)