CD38 Antibody (DA023)

Description

CD38 molecule is a 46-kDa type-II transmembrane glycoprotein with a short N-terminal cytoplasmic tail (20 amino acids) and a long extracellular domain (256 amino acids). It is present on many hematopoietic cells, especially plasma cells, and in some solid tumor tissues.1-3 CD38 is one of the early expressed markers of mature naive B-cell activation and it is useful in identifying functional mature B-lymphocyte subsets.1-3 CD38-positive B-lymphoblastic lymphoma/chronic lymphocytic leukemia has a poor prognosis. — Références — 1. Martin, Flavius, and John F Kearney. "Marginal-zone B cells." Nature reviews. Immunology vol. 2,5 (2002): 323-35. 2. Dono, M et al. "Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents." Journal of immunology (Baltimore, Md. : 1950) vol. 164,11 (2000): 5596-604. 3. Malavasi, Fabio et al. "Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology." Physiological reviews vol. 88,3 (2008): 841-86.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA023

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD38

Localisation

Cell membrane

Usage prévu

IHC (FFPE)