CD34 Antibody (DA022)

Description

CD34 is a cell surface glycophosphoprotein expressed on human hematopoietic progenitor cells and can be used for identifying blast cells.1 CD34 is a marker for vascular endothelial cells and has been shown in literature to be highly sensitive for angiosarcomas and Kaposi's sarcomas.2 In addition, CD34 is expressed in soft tissue tumors such as gastrointestinal stromal tumors (GIST).3 It is also used to differentiate Isolated fibrous tumors, dermatofibrosarcoma protuberans and Malignant phyllodes tumor of the breast. — Références — 1. Torlakovic G, et al. CD34/QBEND10 immunostaining in the bone marrow trephine biopsy: a study of CD34-positive mononuclear cells and megakaryocytes. Arch Pathol Lab Med. 2002; 126:823-8. 2. Nielsen JS, et al. Novel functions of the CD34 family. J Cell Sci. 2008; 121: 3683-92. 3. Kisluk J, et al. Immunohistochemical diagnosis of gastrointestinal stromal tumors - an analysis of 80 cases from 2004 to 2010. Adv. Clin Exp Med. 2013; 22:33-9.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA022

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD34

Localisation

Cell membrane

Usage prévu

IHC (FFPE)