CD31 Antibody (DA021)

Description

CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Endothelial cells also express this marker; therefore, antibodies to CD31 have been used as a tool to identify the vascular origin of neoplasms.1-3 Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells.4 Staining of nonvascular tumors (excluding hematopoietic neoplasms) has not been observed. — Références — 1. Parums DV, et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol. 1990; 43:752-7. 2. De Young BR, et al. CD31 immunoreactivity in carcinomas and mesotheliomas. 1998; 110:374-7. 3. Alles JU, et al. Immunohistochemical and immunochemical characterization of a new endothelial cell-specific antigen. J Histochem Cytochem. 1986; 34:209-14. 4. Alexander-Sefre F, et al. Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol. 2003; 56:786-8.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA021

Isotype

Mouse

Réactivité

Synthetic peptide of human CD31

Localisation

Cell membrane

Usage prévu

IHC (FFPE)