CD3 Antibody (DA024)

Description

CD3’s immunohistochemical detection locates the cytoplasmic component of CD3 protein. Anti-CD3 is considered to be a pan-T-cell marker and reacts with an antigen present at the surface and in the cytoplasm of T lymphocytes. Anti-CD3 is widely used for the identification of immature and mature T-cell malignancies.1-8 With a high specificity and low sensitivity, it is combined with CD45RO to improve its diagnostic accuracy. — Références — 1. Denning SM, et al. Activation of human thymocytes via CD3 and CD2 molecules. In: McMichael AJ, et al. eds. Leucocyte Typing III, White Cell Differentiation Antigens. Oxford-New York-Tokyo. Oxford University Press. 1987; 144-7. 2. Beverley PC, et al. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981; 11:329-34. 3. Clevers H, et al. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. Eur J Immunol. 1988; 18:705-10. 4. Campana D, et al. The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. J Immunol. 1987; 138:648-55. 5. Hedvat CV, et al. Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma. Hum Pathol. 2002; 33:968-74. 6. Karube K, et al. Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification. Am J Surg Pathol. 2003; 27:1366-74. 7. Dogan A, et al. Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. Am J Surg Pathol. 2003; 27:903-11. 8. Axdorph U, et al. T-cell-rich B-cell lymphoma - diagnostic and therapeutic aspects. APMIS. 2002; 110:379-90.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA024

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD3

Localisation

Cell membrane

Usage prévu

IHC (FFPE)