CD23 Antibody (DA224)

Description

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.2 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.2 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.3 CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). — Références — 1. Rowlands DC, et al. Immunohistochemical determination of CD23 expression in Hodgkin’s disease using paraffin sections. J Pathol. 1990; 160:239-43. 2. DiRaimondo F, et al. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002; 94:1721-30. 3. Raghoebier S, et al. Essential differences in oncogene involvement between primary nodal and extranodal large cell lymphoma. Blood. 1991; 78:2680-5.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA224

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD23

Localisation

Cell membrane

Usage prévu

IHC (FFPE)