CD20 Antibody (DA144)

Description

CD20 is a transmembrane protein in late B-cell precursors and mature B-cells that plays a role in regulating proliferation and differentiation. CD20 expression is lost at the plasma cell stage of differentiation.1 Anti-CD20 (pan B-cell)2 has rarely been detected in T-cell malignancies, and is a dependable marker of B-cell lymphomas3 such as DLBCL.4 CD20 expression is present in some thymomas. — Références — 1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4. 2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22. 3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12. 4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA144

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD20

Localisation

Cell membrane

Usage prévu

IHC (FFPE)