CD2 Antibody (DA019)

Description

CD2 is one of the earliest T-cell lineage restricted antigens to appear during T-cell differentiation and only rare CD2+ cells can be found in the bone marrow. Anti-CD2 is a pan-T-cell antigen marker. Anti-CD2 is therefore useful for the identification of virtually all normal T-lymphocytes. It is also very useful in the assessment of lymphoid malignancies as it is expressed in the majority of precursor and mature T-cell lymphomas and leukemias. As with other pan-T-cell antigens, CD2 may be aberrantly deleted in some neoplastic T-cell populations, especially peripheral T-cell lymphomas. When combined with anti-CD25, anti-CD2 may assist in the identification of systemic mastocytosis and mastocytic leukemia.1-4 — Références — 1. Aguilera NS, et al. Arch Pathol Lab Med. 2006; 130:1772-9. 2. Barrionuevo C, et al. Appl Immunohistochem Mol Morphol. 2007; 15:38-44. 3. Bovenschen HJ, et al. Br J Dermatol. 2005; 153:72-8. 4. Foon KA, et al. Blood 1986; 68:1- 31.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA019

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD2

Localisation

Cell membrane

Usage prévu

IHC (FFPE)