CD163 Antibody (DA015)

Description

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130,1 is an acute phase-regulated and signal-inducing transmembrane protein,2 found exclusively on cells of monocytic origin.1 CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes.2 Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin.3 Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms.4 — Références — 1. Buechler C, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophagesby pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103. 2. Kristiansen M, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001; 409:198-201. 3. Etzerodt A, et al. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013; 18: 2352-63. 4. Backe E, Schwarting R, Gerdes J, et al. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrohphage differentiation antigen. J Clin Pathol. 1991; 44:936-45.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA015

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD163

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)