CD15 Antibody (DA014)

Description

CD15 is a carbohydrate antigen with the common trisaccharide structure 3-fucosyl-N-acetyl-lactosamine, also known as Lewis x (Lex) or stage-specific embryonic antigen 1 (SSEA-1).1-3 CD15 is expressed in myeloid cells and mediates neutrophil adhesion to dendritic cells.2-3 CD15 is also expressed in Reed-Sternberg cells and is thus a useful marker for identifying Hodgkin’s lymphoma.1 — Références — 1. Pellegrini W, et al. MMA monoclonal antibody is a superior anti-CD15 reagent for the diagnosis of classical Hodgkin's lymphoma. Haematologica. 2007; 92:708-9. 2. Stocks SC, et al. Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. Biochem J. 1990; 268: 275–80. 3. Gadhoum SZ, et al. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008; 4:751-7.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA014

Isotype

Mouse

Réactivité

Synthetic peptide from human CD15

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)