CD138 Antibody (DA013)

Description

CD138 is a transmembrane heparan sulfate proteoglycan, present mainly in a variety of epithelial tissues, participating in cell proliferation, cell migration, intercellular communication and cell-matrix interactions.1 In lymphoid tissues, CD138 is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 Anti-CD138 is a good marker to selectively identify plasma cells, benign or malignant, in lymphoid tissues3,4 CD138 is also expressed in a variety of epithelial cells.4 — Références — 1. Chilosi M, et al. CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsies. Mod Pathol. 1999; 12:1101-6. 2. Sebestyén A, et al. Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas. Br J Haematol. 1999; 104:412-9. 3. Bayer-Garner IB, et al. Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: shed syndecan-1 accumulates in fibrotic regions. Mod Pathol. 2001; 14:1052-8. 4. O'Connell FP, et al. CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol. 2004; 121:254-63.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA013

Isotype

Mouse

Réactivité

Synthetic peptide of human CD138

Localisation

Cell membrane

Usage prévu

IHC (FFPE)