CD10 Antibody (DA012)

Description

CD10, common acute lymphoblastic leukemia antigen, is expressed by a subset of T follicular helper cells.1,2 CD10 has a direct role in cell growth and apoptosis and has been implicated in tumor cells proliferation.3 CD10 expression has been reported in a variety of tissues; including renal cell carcinoma, hepatocellular carcinoma, and follicular lymphoma.4, 5 — Références — 1. Maguer-Satta V, et al. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem Cells. 2011; 29:389-96. 2. Laurent C, et al. A novel subset of T-helper cells: follicular T-helper cells and their markers. Haematologica. 2010; 95: 356-8. 3. Onak NK, et al. CD10 expression in urothelial bladder carcinomas: staining patterns and relationship with pathologic parameters. Turk J Med Sci. 2010; 40:177-84. 4. Chu P, et al. Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Am J Clin Pathol. 2000; 113: 374-82. 5. Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. P. 220,233,255,265,309.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA012

Isotype

Mouse

Réactivité

Synthetic peptide of human CD10

Localisation

Cell membrane

Usage prévu

IHC (FFPE)