Carbonic Anhydrase IX Antibody (DA141)

Description

Carbonic Anhydrase (CA IX) is part of a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2.1 Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach.1 Data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) making it a useful marker for this type of tumor.2 — Références — 1. Leppilampi, M et al. Carbonic anhydrase isozymes IX and XII in gastric tumors. World J Gastroenterol. 2003; 9:1398-1403. 2. Gupta, R et al. Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms. Am J Surg Pathol. 2009; 33:241-7.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA141

Isotype

Mouse

Réactivité

Synthetic peptide of human Carbonic Anhydrase IX

Localisation

Cell membrane

Usage prévu

IHC (FFPE)