Calretinin Antibody (Polyclonal)

Description

Calretinin is a 29-kDa calcium-binding protein thought to play a role in the cell cycle.1 Anti-calretinin labels mesothelial and Leydig cells under normal and neoplastic conditions.2,3 Anti-calretinin has been shown to be useful in differentiating mesothelioma from adenocarcinomas of the lung and other sources.4-6 The main uses of calretinin are: to distinguish non-tumor mesothelial cells from tumor cells in exudate; to differentiate between adenocarcinomas and mesotheliomas, and to identify cardiac mucinous tumors and stromal tumors of the ovarian sex cord. — Références — 1. Rogers JH. Calretinin: a gene for a novel calcium-binding protein expressed principally in neurons. J Cell Biol. 1987; 105:1343-53. 2. Doglioni C, et al. Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol. 1996; 20:1037-46. 3. Augusto D, et al. Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. Appl Immunohistochem Mol Morphol. 2002; 10:159-62. 4. Barberis MC, et al. Calretinin. A selective marker of normal and neoplastic mesothelial cells in serous effusions. Acta Cytol. 1997; 41:1757-61. 5. Ordóñez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003; 27:1031-51. 6. Abutaily AS, et al. Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies. J Clin Pathol. 2002; 55:662-8.

Caractéristiques

Type

Recombinant polyclonal mouse antibody

Clone

Polyclonal

Isotype

Mouse

Réactivité

Synthetic peptide of human Calretinin

Localisation

Cytoplasm/Nucleus

Usage prévu

IHC (FFPE)