Caldesmon Antibody(DA009)

Description

Caldesmon is a regulatory protein which plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle.1-3 It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.4,5 — Références — 1. Miettinen, Markku, and Jerzy Lasota. "Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis." Archives of pathology & laboratory medicine vol. 130,10 (2006): 1466-78. 2. Watanabe, K et al. "h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor." Human pathology vol. 30,4 (1999): 392-6. 3. McCluggage, W Glenn. "A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms." Advances in anatomic pathology vol. 11,3 (2004): 162-71. 4. Comin, Camilla E et al. "h-Caldesmon, a useful positive marker in the diagnosis of pleural malignant mesothelioma, epithelioid type." The American journal of surgical pathology vol. 30,4 (2006): 463-9. 5. Comin, Camilla E et al. "h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary." The American journal of surgical pathology vol. 31,8 (2007): 1139-48.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA009

Isotype

Mouse

Réactivité

Synthetic peptide of human Caldesmon

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)