Calcitonin Antibody (DA008)

Description

Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism.1 It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin.1,2 Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid3,4 and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.3 — Références — 1. Barrett EJ. The thyroid gland. In: Boron WF, Boulpaep EL, eds. Medical Physiology. A Cellular and Molecular Approach. Updated Second Edition. Philadelphia, PA: Saunders Elsevier; 2012: 1974-1998. 2. Tsutsumi, Y. "Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung." Human pathology vol. 20,9 (1989): 896-902. 3. Matias-Guiu, Xavier, and Ronald De Lellis. "Medullary thyroid carcinoma: a 25-year perspective." Endocrine pathology vol. 25,1 (2014): 21-9. 4. Fischer, Sandra, and Sylvia L Asa. "Application of immunohistochemistry to thyroid neoplasms." Archives of pathology & laboratory medicine vol. 132,3 (2008): 359-72.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA008

Isotype

Mouse

Réactivité

Synthetic peptide from human calcitonin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)