c-MYC Antibody (DA048)

Description

c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc is amplified in many different solid and hematopoeitic tumors.1-5 Immunohistochemistry for c-Myc protein is used to identify the presence of a c-Myc translocation in various tumors, most frequently to aid in the diagnosis of Burkitt lymphoma.5 — Références — 1. Dang, C V. "c-Myc target genes involved in cell growth, apoptosis, and metabolism." Molecular and cellular biology vol. 19,1 (1999): 1-11. 2. Toon, Christopher W et al. "Immunohistochemistry for myc predicts survival in colorectal cancer." PloS one vol. 9,2 e87456. 4 Feb. 2014 3. Naidu, Rakesh et al. "Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction." International journal of molecular medicine vol. 9,2 (2002): 189-96. 4. Yang, Guang et al. "Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression." Cancer vol. 103,6 (2005): 1186-94. 5. Bellan, Cristiana et al. "Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach." Hematological oncology vol. 27,4 (2009): 182-5.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA048

Isotype

Rabbit

Réactivité

Synthetic peptide of human c-MYC

Localisation

Cytoplasm/Nucleus

Usage prévu

IHC (FFPE)