Beta-catenin Antibody (DA006)

Description

Catenin is a cytoskeletal protein, divided into three subtypes: α, β, and γ, which is related to Wnt signaling and cell adhesion mechanism. Beta-catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. Mutations in the beta-catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis (desmoid tumors) of the breast and abdomen and, therefore, is useful in differentiating from other spindle cell neoplasms that may occur in these locations.1-4 — Références — 1. Alman BA, et al. Am J Pathol. 1997; 151:329-34. 2. Li C, et al. Am J Pathol. 1998; 153:709-14. 3. Abraham SC, et al. Hum Pathol. 2002; 33:39-46. 4. Montgomery E, et al. Am J Surg Pathol. 2002; 26:1296-301.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA006

Isotype

Rabbit

Réactivité

Synthetic peptide of human Beta-catenin

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)