bcl-6 Antibody (DA005)

Description

BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.1 In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC).2 BCL6 antibodies stain malignant cells in follicular lymphoma,3 diffuse large B-cell lymphomas,4 Burkitt lymphoma,4 classical Hodgkin lymphoma,5 as well as majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma.6 BCL6 expression has been also seen in anaplastic large cell lymphomas (ALCL).7 — Références — 1. Falini B, et al. Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann Oncol. 1997; 2: 101-4. 2. Aukema SM, et al. Double-hit B-cell lymphomas. Blood 2011; 117:2319-31. 3. Dogan A, et al. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol. 2000; 24:846-52. 4. Carbone A, et al. B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology. Hum Pathol. 2010; 41:621-31. 5. Bai M, et al. B-cell differentiation immunophenotypes in classical Hodgkin lymphomas. Leuk Lymphoma. 2006; 47:495-501. 6. Carbone A, et al. Expression of BCL-6 protein and CD138/syndecan-1 as B-cell markers in Hodgkin's disease. Int J Biol Markers 1999; 14:144-8. 7.Saglam A, et al. Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas. Tumori. 2011; 97:634-8.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA005

Isotype

Mouse

Réactivité

Synthetic peptide from human Bcl-6

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)