Arginase-1 Antibody (DA139)

Description

Arginase is a key metalloenzyme of the urea cycle responsible for the hydrolysis of L-arginine to L-ornithine and urea.1 Two main isoforms exist, arginase-1 and arginase-2, encoded by different genes and with different tissue distributions. The arginase-1 isoform is a cytosolic protein that is produced by normal liver tissue and is typically expressed in hepatocellular carcinoma.1-3 Arginase-1 is used as an immunohistochemical marker to aid in the identification of hepatocellular carcinoma.3,4 — Références — 1. McKnight, Ryan et al. "Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology." Cancer cytopathology vol. 120,4 (2012): 223-9. 2. Sang, Wei et al. "Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine vol. 36,5 (2015): 3881-6. 3. Yan, Benjamin C et al. "Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms." The American journal of surgical pathology vol. 34,8 (2010): 1147-54. 4. Clark, Ian et al. "A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative." Human pathology vol. 69 (2017): 90-95.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA139

Isotype

Rabbit

Réactivité

Synthetic peptide from human Arginase-1

Localisation

Cytoplasm/Nucleus

Usage prévu

IHC (FFPE)