AMACR/p504s Antibody (DA003)

Description

AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker.High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34βE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies. 1-5 — Références — 1. Jiang Z, et al. P504S Am J Surg Pathol. 2001;25:1397-1404 2. Rubin MA, et al. JAMA. 2002;287:1662-1670 3. Luo J, et al. Res. 2002; 62:2220-2226 4. Beach R, et al. Am J Surg Pathol. 2002;26:1588-1596 5. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA003

Isotype

Rabbit

Réactivité

Synthetic peptide from human AMACR/p504s

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)