Alpha-1-Fetoprotein (DA120)

Description

Alpha-fetoprotein (AFP) is a fetal tumor-associated polypeptide of the albuminoid gene family that binds and transports molecules in addition to many other proposed functions.1 This secretory protein is produced by the fetal yolk sac and liver but is found only in trace amounts in adult liver.2 AFP expression by immunohistochemistry is seen in hepatocellular carcinoma (HCC).3 — Références — 1. Mizejewski, G J. "Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants." Experimental biology and medicine (Maywood, N.J.) vol. 226,5 (2001): 377-408. 2. Lazarevich, N L. "Molecular mechanisms of alpha-fetoprotein gene expression." Biochemistry. Biokhimiia vol. 65,1 (2000): 117-33. 3. Yusof, Yasmin Anum Mohd et al. "Immunohistochemical expression of pi class glutathione S-transferase and alpha-fetoprotein in hepatocellular carcinoma and chronic liver disease." Analytical and quantitative cytology and histology vol. 25,6 (2003): 332-8.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA120

Isotype

Rabbit

Réactivité

Synthetic peptide from human Alpha-1-Fetoprotein

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)