BIO SB ZAP-70 (2F3.2), MMab
For In Vitro Diagnostic Use
Description
ZAP-70 is an abbrevation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member of the protein-tyrosine kinase family. ZAP-70 is normally expressed in T-cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 antibody in B-cells is used as a prognostic marker in identifying different forms of Chronic Lymphocytic Leukemia (CLL). ZAP-70 protein is expressed in leukemic cells in approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.
Synonymes
SRK, ZAP 70, ZAP70, anti-ZAP-70, anti ZAP-70, anti-ZAP 70, anti-ZAP70, anti ZAP 70, anti ZAP70, anti-SRK, anti SRK, 70 kDa zeta associated protein, FLJ17670, FLJ17679, STD, syk related tyrosine kinase, Tyrosine protein kinase ZAP 70, TZK, zeta chain TCR associated protein kinase 70kDa, zeta chain associated protein kinase 70kD, 70 kDa zeta chain associated protein
Caractéristiques
- Type
- Mouse Polyclonal
- Clone
- 2F3.2
- Isotype
- IgG2a
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Tonsil, Lymph Node, Chronic Lymphocytic Leukemia
- Usage prévu
- For In Vitro Diagnostic Use
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