TTF-1 (8G7G3/1), MMab

Description

Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific to the thyroid, lung and diencephalon. It is also known as thyroid-specific enhancer binding protein and NKX-2. It is used as a marker to determine if a tumor oringinates in the lung or thyroid. TTF-1 positive cells are found in Type II pneumocytes and Clara cells in the lung. In the thyroid, follicular and parafollicular cells are positive. TTF-1 antibody is useful in differentiating primary Adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. It can also be used to differentiate Small- Cell Lung Carcinoma from lymphoid infiltrates. For lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. Small-Cell Carcinomas (of any primary site) are usually positive.

Caractéristiques

Type

Mouse Monoconal

Clone

8G7G3/1

Isotype

IgG1

Réactivité

Paraffin, Frozen

Localisation

Nuclear

Contrôle

Adenocarcinoma of Lung, Normal Lung, Thyroid

Usage prévu

For In Vitro Diagnostic Use