BIO SB TRPS1 (EP392), RMab
For In Vitro Diagnostic Use
Description
The trichorhinophalangeal syndrome 1 (TRPS-1) gene belongs to the GATA transcription factor family. TRPS-1 has been identified as a highly prevalent gene in Breast Cancer, expressed in >90% of estrogen receptor alpha (ERα)+ and ERα− BC subtypes. As of today, the GATA3 tumor marker is commonly used to determine the breast origin for ER-positive and low-grade Breast Cancer, but is low in sensitivity <20% in metaplastic Breast Carcinoma such as Triple-Negative Breast Cancer (TNBC). In contrast, TRPS1 and GATA3 had comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) Breast Carcinomas, but TRPS1 had higher expression than GATA3 in metaplastic (86% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC cases. TCGA data indicated that the (TRPS1) is a specific gene for Breast Carcinoma across 31 solid tumor types, including all 4 subtypes of Breast Carcinoma such as ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. TRPS1 produced no or little expression in Lung, Pancreatic, Colon, Gastric Adenocarcinomas, Urothelial, Renal, or Ovarian Carcinomas, or Melanoma; it can be concluded that the TRPS1 marker is a sensitive and specific marker for Breast Cancer and particularly for TNBC.
Synonymes
TRPS1, anti-trps1 antibody, anti trps1, trichorhinophalangeal syndrome I human, Trps1, Zinc finger transcription factor Trps1, TRPS1 shRNA DNA plasmid, TRPS1 shRNA plasmid, TRPS1 shRNA lentiviral particle, TRPS1 lentiviral particle, TRPS1 gene silencer, TRPS1 RNAi primers/span>
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP392
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Breast, Ductal Breast Carcinoma, Triple Negative Carcinoma, Fallopian Tubes
- Usage prévu
- For In Vitro Diagnostic Use
Intéressé par ce produit ?
Indiquez la référence et le conditionnement souhaités, nous revenons vers vous rapidement.