BIO SB T-Bet / TBX-2 (EP263), RMab
For In Vitro Diagnostic Use
Description
T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T cells to Th1 development. T-bet antibody is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pregerminal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for T-bet. Therefore, T-bet antibody should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.
Synonymes
T bet, Tbet, Tbx21, anti-T-bet, anti T-bet, anti-T bet, anti-Tbet, anti T bet, anti Tbet, anti-TBX21, anti TBX21, T box 21, T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor, T cell specific T box transcription factor T bet, T PET, Tblym, transcription factor TBLYM, TBT1
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP263
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Spleen, Tonsil, Cervix, Lymphoblastic lymphoma, Hairy Cel leukemia, Bladder TCC
- Usage prévu
- For In Vitro Diagnostic Use
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