BIO SB SS18-SSX (RBT-SS18-SSX), RMab
For In Vitro Diagnostic Use
Description
Expression of SS18-SSX fusion protein is the hallmark of Synovial Sarcoma, a type of soft tissue sarcoma that accounts for 5-10% of all soft tissue sarcoma. Diagnosis of synovial sarcoma can be challenging due to histologic overlap with a range of other tumors, therefore, IHC is routinely used in differential diagnosis. SS18-SSX is a fusion oncoprotein created during chromosome translocation in which the SS18 gene on chromosome 18 is fused to the SSX1, SSX2, or SSX4 gene on the X chromosome. Normally, SS18 subunit and BAF47 subunit bind to BAF (mSWI/SNF) complex which produces polycomb-mediated repression of Sox-2 and cessation of proliferation. SS18-SSX renders the BAF chromatin remodeling complex aberrant through the addition of SSX to the SS18 subunit and the loss of BAF47 subunit from the BAF (mSWI/SNF) complex. The altered complexes reverse the polycomb-mediated repression and result in the activation of Sox-2 and uncontrolled proliferation.
Synonymes
ss18-ssx, anti-ss19-ssx, anti ss18-ssx, SSX1, SSX2B, SSX3, SSX4B, SSX5, SSX7, SSX8, SSX9, SSX2, SSX4, SSX6, cancer testis antigen 5 1, cancer testis antigen 5 2, Cancer testis antigen 5 3, Cancer testis antigen 5 4, cancer testis antigen family 5 member 1, cancer testis antigen family 5 member 2b, CT5 1, CT5 2, CT5 2b, CT5 3, CT5 4, HOM MEL 40, Protein SSX1, protein SSX2, Protein SSX3, Protein SSX4, protein SSX5, Protein SSX7, Protein SSX8, Protein SSX9, sarcoma synovial X chromosome related 1, SSRC, SSX, Synovial sarcoma X breakpoint 1, Synovial sarcoma X breakpoint 2, synovial sarcoma X breakpoint 2B, synovial sarcoma X breakpoint 3, synovial sarcoma X breakpoint 3 isoform a, synovial sarcoma X breakpoint 4B, synovial sarcoma X breakpoint 5, synovial sarcoma X breakpoint 7, synovial sarcoma X breakpoint 8, synovial sarcoma X breakpoint 9, tumor antigen HOM MEL 40
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-SS18-SSX
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Synovial Sarcoma with the SS18-SSX fusion
- Usage prévu
- For In Vitro Diagnostic Use
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