BIO SB SOX-2 (RM427), RMab
Description
SRY (sex determining region Y)-box 2, also known as SOX-2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. It is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX-2 antibody is expressed in fetal brain and is used as a marker for multipotential neural stem cells. In tumors, SOX-2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract. SOX-2 may be useful in the identification of embryonal carcinoma. In stage I lung adenocarcinomas, SOX2 seems to be an independent predictor of poor outcome and may help stratify patients at increased risk for recurrence.
Synonymes
Sox2, anti-sox-2, anti-sox2, sox 2, sox-2, anti sox-2, Sox 2,anti Sox 2, anti Sox-2, anti Sox2, anti SRY-related HMG-box transcription factor 2, anti-Sox 2, anti-Sox-2, anti-Sox2, anti-SRY-related HMG-box transcription factor 2, SRY-related HMG-box transcription factor 2, ANOP3, MCOPS3, MGC2413, SRY sex determining region Y box 2, SRY related HMG box gene 2, transcription factor SOX 2, transcription factor SOX2
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RM427
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Brain, Oligodendroglioma, Squamous Cell Carcinoma
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