SOX-11 (CL0142), MMab

Description

Transcription factor SOX-11 is a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and plays a role in tumorigenesis and adult neurogenesis. SOX-11 antibody is normally expressed in the developing human central nervous system, medulloblastoma, and glioma. SOX-11 antibody nuclear expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas, with a stronger and more homogeneous Immunostain than cyclin D1. Absence of SOX-11 expression in mantle cell lymphoma (MCL) may be a characteristic of indolent MCL. Sensitivity and specificity for combined SOX-11 and cyclin D1 immunohistostaining in the diagnosis of cutaneous mantle cell lymphoma are both 100%. SOX-11 has also been detected in rare cases of Burkitt lymphoma, lymphoblastic lymphoma and T cell prolymphocytic leukemia and overexpression can be seen in malignant gliomas.

Caractéristiques

Type

Mouse Monoclonal

Clone

CL0142

Isotype

IgG2a

Réactivité

Paraffin, Frozen

Localisation

Nuclear

Contrôle

Mantle Cell Lymphoma

Usage prévu

For In Vitro Diagnostic Use