S100A8/MRP8 (RBT-MRP8), RMab

Description

Myeloid Related Protein 8 (MRP8), also known as S100A8, is a calcium binding protein that belongs to the S100 family. By a Ca2+ dependent manner, S100A8/A9 forms Calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and expressed on the membrane of monocytes. S100A8 is expressed during myeloid differentiation and chronic inflammations, and it is expressed constitutively or induced in epithelial cells during dermatose. S100A8 is expressed in cells with myeloid origin, including granulocytes, monocytes and macrophages, and it is observed in blood granulocytes and monocytes. It is also expressed in infiltrate macrophages during inflammatory reactions, but not in normal tissue macrophages. S100A8 also reacts with activated microglial cells in human cerebral malaria. In tumors, positive staining of S100A8 has been observed in various cancers including pancreatic cancer, and it has been linked to inflammation-associated cancers.

Caractéristiques

Type

Rabbit Monoclonal

Clone

RBT-MRP8

Isotype

IgG

Réactivité

Human

Localisation

Cytoplasmic

Usage prévu

S100A8/MRP8 (RBT-MRP8) , rabbit monoclonal antibody, is a primary antibody intended for laboratory use by trained laboratory personnel in an immunohistochemical (IHC) assay to qualitatively identify the S100A8/MRP8 protein by light microscopy in normal and/or pathological formalin-fixed, paraffin-embedded (FFPE) human tissue. The clinical interpretation of any staining or its absence should be performed by a qualified pathologist and complemented by morphological studies using proper controls and evaluated within the context of the patient’s clinical history and other diagnostic tests.