BIO SB S-100 (4C4.9), MMab
For In Vitro Diagnostic Use
Description
S-100 protein is a type of low-molecular weight protein found in vertebrates, characterized by two calcium-binding sites of the helix-loop-helix conformation. S-100 antibody expression is normally present in cells derived from the neural crest (Schwann cells, melanocytes and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells. Several members of the S-100 protein family are useful as markers for certain tumors and epidermal differentiation. The S-100 protein can be found in melanomas, 50% of Malignant Peripheral Nerve Sheath Tumors, and Clear Cell Sarcomas. Almost all Malignant Melanomas and cases of Histiocytosis X are positive for S-100 antibody. Despite the fact that S-100 protein is a ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly Melanomas.
Synonymes
S100, S100A, S100A1, S 100, anti-S-100, anti S-100, anti-S 100, anti-S100, anti S 100, anti S100, S100 protein A1 (S100A1), anti-S100 protein A1 (S100A1), anti S100 protein A1 (S100A1), S100 calcium-binding protein A1, S100-alpha, cardiac/skeletal muscle expressing, Z-disc/sarcoplasmic reticulum localizing, EF-hand type helix-loop-helix structural domain-containing, calcium (Ca2+)-binding protein, Damage-associated molecular patterns (DAMPs) related, noninfectious inflammatory response protein specific, anti-S100 calcium-binding protein A1, anti S100 calcium-binding protein A1, anti-S100A, anti S100A, anti-S100-alpha, anti S100-alpha, anti-cardiac/skeletal muscle expressing, Z-disc/sarcoplasmic reticulum localizing, anti cardiac/skeletal muscle expressing, Z-disc/sarcoplasmic reticulum localizing, anti-EF-hand type helix-loop-helix structural domain-containing, calcium (Ca2+)-binding protein, anti EF-hand type helix-loop-helix structural domain-containing, calcium (Ca2+)-binding protein, anti-Damage-associated molecular patterns (DAMPs) related, anti Damage-associated molecular patterns (DAMPs) related, anti-noninfectious inflammatory response protein specific, anti noninfectious inflammatory response protein specific, protein S100 A1, S 100 protein alpha chain, S100 alpha, S100 calcium binding protein A1, S100 protein alpha polypeptide, S 100 protein subunit alpha
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- 4C4.9
- Isotype
- IgG2a
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Melanoma
- Usage prévu
- For In Vitro Diagnostic Use
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