BIO SB PMS2 (RBT-PMS2), RMab
For In Vitro Diagnostic Use
Description
“PMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI.”
Synonymes
anti-pms2, anti pms2, pms-2, anti-pms-2, anti pms-2, DNA mismatch repair protein PMS2, mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMS2 postmeiotic segregation increased 2 S cerevisiae, PMS2CL, PMSL2
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-PMS2
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Breast, Skin, Cervix, Tonsil, TCC, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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