BIO SB PDGFR-B (RBT-PDGFRB), RMab
For In Vitro Diagnostic Use
Description
Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. The PDGFR-B antibody detects translocation of the PDGFR gene with the Tel gene, which is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Synonymes
CD140B, PDGFR, PDGFRB, sc374573, PDGFR-β, PDGFR-beta, PDGFR-b, PDGFR b, PDGFR β, PDGFRβ, anti CD140B, anti PDGFR, anti PDGFR β, anti PDGFR-β, anti PDGFRB, anti PDGFRβ, anti-CD140B, anti-PDGFR, anti-PDGFR β, anti-PDGFR-β, anti-PDGFRB, anti-PDGFRβ, Beta platelet derived growth factor receptor, Beta type platelet derived growth factor receptor, CD140 antigen like family member B, JTK12, PDGF R beta, PDGFR 1, PDGFR beta, PDGFR1, platelet derived growth factor receptor 1, platelet derived growth factor receptor beta, platelet derived growth factor receptor beta polypeptide, pdgfrb, anti-pdgfrb, anti-pdgfr-b, anti pdgfr-b, anti pdgfrb
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-PDGFRB
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Brain, Testis, Breast, Colon, Fallopian Tube
- Usage prévu
- For In Vitro Diagnostic Use
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