BIO SB panTRK (RBT-TRK)- RMab
For In Vitro Diagnostic Use
Description
panTRK is a new rabbit monoclonal antibody for immunohistochemistry from Bio SB. TRK (tropomyosin receptor kinase) A, B, and C are encoded by NTRK1, NTRK2 , and NTRK3 genes respectively. Each protein is activated by different neurotrophins: TRKA is activated by Nerve growth factor, TRKB by brain-derived neurotrophic factor, and TRKC by NT-3. The TRK receptors are a family of tyrosine kinases that regulate synaptic strength and plasticity in the mammalian nervous system. The activation of TRK receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells. TRK family of receptor tyrosine kinases are of interest as the NTRK genes that encode them are involved in gene fusions identified in a wide range of adult and pediatric tumors. TRK, was initially identified in a colon carcinoma, is frequently activated in thyroid papillary carcinomas. PanTRK IHC has shown to be positive in most cases with NTRK fusion transcripts confirmed by Archer. One study established the PanTRK IHC sensitivity and specificity for transcribed NTRK fusions to be 95.2% and 100%, respectively. All positive IHC cases had cytoplasmic staining while the following fusion partner-specific patterns were discovered: all LMNA-NTRK1 fusions displayed nuclear membrane accentuation, all TPM3/4 fusions displayed cellular membrane accentuation, and half of ETV6-NTRK3 fusions displayed nuclear staining. In another study, Immunohistochemistry screening in 1043 various solid tumors showed TRKA expression in 1.6% of samples, including Colorectal, Lung Cancer, Biliary Carcinoma and Thyroid Cancers. NTRK gene fusions have been identified in both pediatric and adult primary central nervous system tumors, including Glioblastoma Multiforme, Pediatric Gliomas and Astrocytomas. Various translocations involving NTRK 1 or NTRK3 have been reported in Spitzoid melanocytic neoplasms, as well as in compound Spitz Nevi. TRK fusions have also been reported in Intrahepatic Cholangiocarcinomas, Breast Cancer, quadruple wild-type (ETV6-NTRK3) Gastrointestinal Stromal Tumors, Gallbladder Adenocarcinomas, Pancreatic Carcinomas, Sinus-Nasal Low-Grade Non-Intestinal-type Adenocarcinomas and Neuroendocrine Tumors of the small bowel. In addition to being present in solid tumors, NTRK gene fusions have been also detected in Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia.
Synonymes
NTRK1, TRKA, Ntrk2, NTRK3, trkB, TRKC, p- Trk, sp Trk, pTrk, anti NTRK1, anti NTRK2, anti NTRK3, anti p Trk, anti p-Trk, anti Pan Trk, anti pTrk, anti TRKA, anti TRKB, anti TRKC, anti-NTRK1, anti-NTRK2, anti-NTRK3, anti-p Trk, anti-p-Trk, anti-Pan Trk, anti-pTrk, anti-TRKA, anti-TRKB, anti-TRKC, Pan Trk, Oncogene TRK, p140 TrkA, TRK, Trk A, TRK1, TRK1 transforming tyrosine kinase protein, Tyrosine kinase receptor A, High affinity nerve growth factor receptor precursor, Neurotrophic tyrosine kinase receptor type 2, Neurotrophic tyrosine kinase receptor type 3, Tkr, Tkrb, Trk B, Trk C, TrkB tyrosine kinase, TrkC tyrosine kinase, ETS related protein neurotrophic receptor tyrosine kinase fusion protein, ETV6 NTRK3 fusion, GP145 TrkB, tyrosine kinase receptor B, tyrosine kinase receptor C, BDNF tropomyosine receptor kinase B, gp140trk, neurotrophin 3, Ntrk3 tv3, tropomyosin related kinase A, tropomyosin related kinase B, Tyrosine kinase receptor
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-TRK
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear,Cytoplasmic
- Contrôle
- Brain, Lung Neuroendocrine
- Usage prévu
- For In Vitro Diagnostic Use
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