BIO SB p53 (DO7), MMab
For In Vitro Diagnostic Use
Description
p53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence. Mutations involving p53 antibody expression have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.
Synonymes
p53 antibody do1, DO1, DO 1, TP53, Trp53, anti-p53, anti p53, anti-TP53, anti-Trp53, anti TP53, anti Trp53, anti tumor suppressor protein p53, anti-tumor suppressor protein p53, tumor suppressor protein p53, CI 42kD, complex I 42kD, NADH dehydrogenase ubiquinone 1 alpha subcomplex 10 42kDa, NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 10 mitochondrial, NADH ubiquinone oxidoreductase 42 kDa subunit
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- DO7
- Isotype
- IgG2b/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Lung, Breast, Ovarian, Prostate, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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