BIO SB p27 (SX53G8), MMab
For In Vitro Diagnostic Use
Description
p27KIP1 is a cell cycle regulatory mitotic inhibitor of Cdk activity. p27KIP1 is a candidate-tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Low p27 antibody expression has been associated with unfavorable prognosis in Renal-cell Carcinoma,Colon Carcinoma, Small Breast Carcinomas, Non-small-cell Lung Carcinoma, Hepatocellular Carcinoma, Multiple Myeloma, lymph node metastases in Papillary Carcinoma of the Thyroid, and a more aggressive phenotype of Carcinoma in the Cervix.
Synonymes
CDKN1B, KIP1, anti-p27, anti p27, p27/Kip1, anti-p27/Kip1, anti p27/Kip1, anti- KIP1, anti KIP1, CDKN4, Cyclin dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B p27 Kip1, Cyclin dependent kinase inhibitor p27, MEN1B, MEN4, P27KIP1, P27KIP 1, CDKN 4, MEN 1B, Kip 1, MEN 4, AA408329, AI843786, OTTMUSP00000023376, OTTMUSP00000023377, p27
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- SX53G8
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Prostate, Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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