BIO SB p21 (DCS-60.21),MMab
For In Vitro Diagnostic Use
Description
p21 is a potent cyclin-dependent kinase inhibitor. The p21 protein binds to and inhibits the activity of cyclin-CDK2 or -CDK1 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a varity of stimuli. In addition to growth arrest, p21 can mediate cellular senescence. p21 can also interact with proliferating cell nuclear antigen (PCNA) and plays a regulatory role in S phase DNA replication and DNA damage repair. Normal cells typically display a rather intense nuclear p21 antibody expression. Loss of p21 expression has been associated with poor prognosis in several carcinomas including Gastric Carcinoma, Non-Small Cell Lung Carcinoma and Thyroid Carcinoma.
Synonymes
Cdkn1a, CIP1, Waf1, anti-p21, anti p21, anti CDKN1A, anti CIP1, anti WAF1, anti-CDKN1A, anti-CIP1, anti-WAF1, CAP20, CDKI, Cdkn1, cyclin dependent kinase inhibitor 1, cyclin dependent kinase inhibitor 1A P21, mda6, Melanoma differentiation associated protein, P21, p21 WAF1 CIP1, p21Cip1, p21WAF, SDI1
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- DCS-60.2
- Isotype
- IgG2a
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Nuclear
- Contrôle
- Tonsil, Colon, Fallopian Tube, Breast Cancer, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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