BIO SB MSH6 (EP49), RMab
For In Vitro Diagnostic Use
Description
MSH6 is a rabbit monoclonal antibody (RMab) for immunohistochemistry from Bio SB. MSH6, also known as mutS homolog 6, is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts.
Synonymes
msh-6, anti msh6, anti-msh6, anti msh-6, gtbp, anti-gdbp, SH6, DNA mismatch repair protein Msh6, G T mismatch binding protein, GTBP, GTMBP, HNPCC5, HSAP, mutS homolog 6 E coli, MutS alpha 160 kDa subunit, p160, sperm associated protein, hMSH6
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP49
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Colon Mucosa, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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