BIO SB MSH2 (BSB-147), MMab
For In Vitro Diagnostic Use
Description
MSH2 is a mouse monoclonal antibody for immunohistochemistry from Bio SB. MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 antibody expression is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Synonymes
COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC, HNPCC1, homolog 2 colon cancer nonpolyposis type 1 E coli, MutS protein homolog 2, msh-2, anti-msh2, anti-msh-2, anti-msh-2, anti msh2, anti msh-2, anti msh 2
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-147
- Isotype
- IgG1
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Colon, Skin, Breast, Tonsil, Fallopian Tube, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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