BIO SB MLH1 (RBT-MLH1), RMab
For In Vitro Diagnostic Use
Description
MLH1 is a new antibody for immunohistochemistry from Bio SB. MLH1 is a mismatch repair gene of around 87 kDa, commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. In a high proportion of patients with microsatellite instability (MSI-H), the MLH1 protein is typically deficient. This protein deficiency is linked to the autosomal dominant condition of Hereditary Non-Polyposis Colon Cancer. The MLH1 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite stable counterparts.
Synonymes
MLH1, mlh-1, mlh -1, mlh- 1,DNA mismatch repair protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, mutL homolog 1 colon cancer nonpolyposis type 2 E coli, MutL protein homolog 1, anti mlh1, anti-mlh1, mlh-1, anti mlh-1, anti-mlh-1
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-MLH1
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Testis, Tonsil, Colon, Kidney, Colon Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
Intéressé par ce produit ?
Indiquez la référence et le conditionnement souhaités, nous revenons vers vous rapidement.