BIO SB MDR-1 (JSB-1), MMab
For In Vitro Diagnostic Use
Description
P-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood. MDR-1 antibody is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.
Synonymes
ABCB1, Mdr1, Abcb1b, Mdr 1, anti-MDR1, anti MDR1, anti-ABCB1, anti-Abcb1b, anti ABCB1, anti Abcb1b, Mdr-1, CD243, P-glycoprotein (P-gp), anti-Mdr-1, anti Mdr-1, anti-CD243, P-glycoprotein (P-gp), anti CD243, P-glycoprotein (P-gp), ABC20, ATP binding cassette sub family B member 1, ATP binding cassette sub family B MDR TAP member 1, CD243, CLCS, colchicin sensitivity, doxorubicin resistance, GP170, MGC163296, multidrug resistance protein 1, P glycoprotein 1, P GP, Pgy1, Abcb1a, Abcb4, ATP binding cassette sub family B member 1A, ATP binding cassette sub family B MDR TAP member 1A, ATP binding cassette sub family B MDR TAP member 1B, ATP binding cassette sub family B MDR TAP member 4, ATP binding cassette subfamily B member 1A, ecotropic viral integration site 32, Evi32, mdr, mdr 3, MDR1A, Mdr1b, Mdr3, multi drug resistance 3, multidrug resistance protein 3, multiple drug resistant 1a, P glycoprotein 3, Pgp, Pgy 1, Pgy 3, Pgy3, ATP binding cassette sub family B member 1B, Multidrug resistance protein 1A, Multidrug resistance protein 1B
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- JSB-1
- Isotype
- IgG1
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Skeletal Muscle, Kidney, Adrenal, Liver
- Usage prévu
- For In Vitro Diagnostic Use
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