LRG1 (BSB-174), MMab

Description

Leucine-rich alpha-2-glycoprotein 1 or LRG1 is a protein which in humans is encoded by the gene LRG1. LRG1 is involved in protein-protein interaction, signal transduction, and cell adhesion and development. Considerable data show that LRG1 is a contributing factor to the disease process, such as cancer, diabetes, cardiovascular, neurological, and inflammatory disorders. Immunohistochemistry on tissue sections demonstrated that alveolar epithelial cells, renal tubular epithelial cells and interstitial cells express LRG1 in the lung, kidney and heart respectively, while cell-specific loss of function in vivo experiments showed that fibroblasts may represent a key source of LRG1 in the normal skin. LRG1 may be an acute phase protein, showing elevated expression following injection of known inflammatory agents. LRG1 was also shown to promote angiogenesis in a wide variety of pathological settings, including Diabetic Nephropathy, Diabetic Retinopathy, Age-related Macular Degeneration, and cancers.

Caractéristiques

Type

Mouse Monoclonal

Clone

BSB-174

Isotype

IgG2

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Nuclear

Contrôle

Placenta, Kidney, Pancreas, Spleen

Usage prévu

For In Vitro Diagnostic Use