Laminin-R / RPSA (BSB-144), MMab

Description

Laminin receptor (Ribosomal Protein SA or 67LR) is a 67kDa protein in the extracellular matrix, coded by a 5,833 bp gene on Chromosome 3,containing seven exons and six introns. Laminin-R is involved in cellular adhesion to basement membranes and signal transduction pathways after binding the ligand Integrin-1. The receptor is also involved in pathways of cytoskeletal movement, chromatin structure, cellular migration, stress response, ribosomal function, translation, and rRNA processing. Laminin-R is also a receptor for green tea polyphenol and mediator in the Nitrous Oxide (eNOS) pathways used to force cancer cells into apoptosis. The 37kDa precursor protein, known also as p40, is a highly-conserved protein in the 40S ribosomal subunit. Laminin-R antibody has been found to be overexpressed in Breast, Colorectal, Pancreatic, Prostate, and Cervical Cancer, and in Lymphomas. Laminin-R interacts with cyclin-dependent kinases and inhibitors to control G1/S, S/G2 and G2/M phase cell cycle arrest; down-regulation of the receptor is correlated with arrested cell growth and a reduction in the development of tumors. Laminin-R has also been found to be involved in regulation of Survivin expression, as well as cancer metastasis and drug resistance.

Caractéristiques

Type

Mouse Monoclonal

Clone

BSB-144

Isotype

IgG1

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Placenta, Kidney, Prostate, Tonsil, Spleen, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma

Usage prévu

For In Vitro Diagnostic Use